Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion

The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and in effective labeling of the bacteria for phagocytosis. In addition, formation of the membrane attack complex is responsible for direct killing ...

متن کامل

Bacterial Lipopolysaccharide-Dependent Complement Evasion

Finding factors that control complement (C) components deposition on bacterial cells is the way to explain the sophisticated mechanism of bacteraemia. Lipopolysaccharide (LPS, endotoxin) is a surface antigen found in the cell walls of Gram-negative bacteria, such as Salmonella [1]. LPS action on the human body is often considered in the context of sepsis, which is characterized by an excessive ...

متن کامل

Incorporation of host complement regulatory proteins into Newcastle disease virus enhances complement evasion.

Newcastle disease virus (NDV), an avian paramyxovirus, is inherently tumor selective and is currently being considered as a clinical oncolytic virus and vaccine vector. In this study, we analyzed the effect of complement on the neutralization of NDV purified from embryonated chicken eggs, a common source for virus production. Fresh normal human serum (NHS) neutralized NDV by multiple pathways o...

متن کامل

Membrane complement regulatory proteins.

A number of proteins anchored on the cell surface function to protect host tissues from bystander injury when complement is activated. In humans, they include decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46), complement receptor 1 (CR1, CD35) and CD59. Although disease conditions directly attributable to abnormal function of these proteins are relatively rare, it has...

متن کامل

Complement regulatory proteins and autoimmunity.

To discriminate self from non-self is an essential issue in the immune system. Autologous cells are protected against complement-mediated cell injury by the self-recognition mechanism using complement regulatory proteins composed of complement receptor type 1 (CR1, CD35), membrane cofactor protein (MCP, CD46), decay accelerating factor (DAF, CD55) and homologous restriction factor (protectin, C...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Frontiers in Microbiology

سال: 2016

ISSN: 1664-302X

DOI: 10.3389/fmicb.2016.02004